An eye on insulin

J Clin Invest. 2003 Jun;111(12):1817-9. doi: 10.1172/JCI18927.

Abstract

Diabetic retinopathy, the most frequent complication of diabetes and leading cause of vision loss, involves vascular and neural damage in the retina. Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Diabetic Retinopathy / etiology*
  • Diabetic Retinopathy / pathology
  • Diabetic Retinopathy / physiopathology
  • Humans
  • Insulin / physiology*
  • Insulin-Like Growth Factor I / physiology
  • Mice
  • Models, Biological
  • Neovascularization, Pathologic
  • Receptor, IGF Type 1 / physiology
  • Receptor, Insulin / physiology
  • Retinal Vessels / pathology

Substances

  • Insulin
  • Insulin-Like Growth Factor I
  • Receptor, IGF Type 1
  • Receptor, Insulin