Alveolar soft-part sarcoma responding to interferon alpha-2b

K J Roozendaal; B de Valk; J J A ten Velden; H J van der Woude; B B R Kroon

doi:10.1038/sj.bjc.6601074

Alveolar soft-part sarcoma responding to interferon alpha-2b

Br J Cancer. 2003 Jul 21;89(2):243-5. doi: 10.1038/sj.bjc.6601074.

Authors

K J Roozendaal¹, B de Valk, J J A ten Velden, H J van der Woude, B B R Kroon

Affiliation

¹ Department of Haematology/Medical Oncology, Onze Lieve Vrouwe Gasthuis, Eerste Oosterparkstraat 179, 1090 HM Amsterdam, The Netherlands. K.J.Roosendaal@olvg.nl

Abstract

A 23-year-old woman with an alveolar soft-part sarcoma of her calf with pulmonary metastases unresponsive to chemotherapy is described. Interferon (IFN) alpha-2b induced an impressive tumour response still ongoing after IFN treatment had to be stopped because of a psychosis. An explanation of this effect is still speculative.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Agents / adverse effects
Antineoplastic Agents / pharmacology*
Female
Humans
Interferon alpha-2
Interferon-alpha / adverse effects
Interferon-alpha / pharmacology*
Psychotic Disorders / etiology
Recombinant Proteins
Sarcoma / drug therapy*
Sarcoma / pathology
Soft Tissue Neoplasms / drug therapy*
Soft Tissue Neoplasms / pathology
Treatment Outcome

Substances

Antineoplastic Agents
Interferon alpha-2
Interferon-alpha
Recombinant Proteins