Elasticity in extracellular matrix 'shape modules' of tendon, cartilage, etc. A sliding proteoglycan-filament model

J Physiol. 2003 Dec 1;553(Pt 2):335-43. doi: 10.1113/jphysiol.2003.050179. Epub 2003 Aug 15.

Abstract

Connective tissues (CTs), which define bodily shape, must respond quickly, robustly and reversibly to deformations caused by internal and external stresses. Fibrillar (elastin, collagen) elasticity under tension depends on molecular and supramolecular mechanisms. A second intra-/inter-molecular pair, involving proteoglycans (PGs), is proposed to cope with compressive stresses. PG interfibrillar bridges ('shape modules'), supramolecular structures ubiquitously distributed throughout CT extracellular matrices (ECMs), are examined for potential elastic properties. L-iduronate residues in shape module decoran PGs are suggested to be molecular springs, cycling through alternative conformations. On a larger scale, anionic glycosaminoglycan (AGAG) interfibrillar bridges in shape modules are postulated to take part in a sliding filament (dashpot-like) process, which converts local compressions into disseminated tensile strains. The elasticity of fibrils and AGAGs, manifest at molecular and larger-scale levels, provides a graduated and smooth response to stresses of varying degrees. NMR and rheo NMR, computer modelling, electron histochemical, biophysical and chemical morphological evidence for the proposals is reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aggrecans
  • Animals
  • Cartilage / chemistry
  • Cartilage / physiology
  • Chondroitin Sulfates / chemistry
  • Chondroitin Sulfates / physiology
  • Decorin
  • Elasticity
  • Elastin / chemistry
  • Elastin / physiology
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / physiology*
  • Extracellular Matrix Proteins / chemistry
  • Extracellular Matrix Proteins / physiology
  • Fibrillar Collagens / chemistry
  • Fibrillar Collagens / physiology*
  • Glycosaminoglycans / chemistry
  • Glycosaminoglycans / physiology
  • Lectins, C-Type
  • Models, Biological*
  • Models, Molecular
  • Molecular Conformation
  • Proteoglycans / chemistry
  • Proteoglycans / physiology*
  • Stress, Mechanical
  • Tendons / chemistry
  • Tendons / physiology

Substances

  • Aggrecans
  • Decorin
  • Extracellular Matrix Proteins
  • Fibrillar Collagens
  • Glycosaminoglycans
  • Lectins, C-Type
  • Proteoglycans
  • Chondroitin Sulfates
  • Elastin