Abstract
Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone-benzene afforded a ca. 2:1:2:1 mixture of the stilbenolignan (+/-)-aiphanol (1) and congeners 2-4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemical synthesis
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Angiogenesis Inhibitors / pharmacology
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Animals
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Aorta / drug effects
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemical synthesis
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Cyclooxygenase Inhibitors / pharmacology
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Dose-Response Relationship, Drug
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Inhibitory Concentration 50
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Isoenzymes / antagonists & inhibitors
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Magnetic Resonance Spectroscopy
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Membrane Proteins
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Prostaglandin-Endoperoxide Synthases
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Rats
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Stereoisomerism
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Stilbenes / chemical synthesis*
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Stilbenes / chemistry*
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Stilbenes / pharmacology*
Substances
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Angiogenesis Inhibitors
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Membrane Proteins
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Stilbenes
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aiphanol
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Cyclooxygenase 1
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Ptgs1 protein, rat