Developmental acquisition of sensory transduction in hair cells of the mouse inner ear

Nat Neurosci. 2003 Oct;6(10):1019-20. doi: 10.1038/nn1120. Epub 2003 Sep 14.

Abstract

Sensory transduction in hair cells requires assembly of membrane-bound transduction channels, extracellular tip-links and intracellular adaptation motors with sufficient precision to confer nanometer displacement sensitivity. Here we present evidence based on FM1-43 fluorescence, scanning electron microscopy and RT-PCR that these three essential elements are acquired concurrently between embryonic day 16 and 17, several days after the appearance of hair bundles, and that their acquisition coincides with the onset of mechanotransduction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Membrane / physiology
  • Cell Membrane / ultrastructure
  • Cilia / physiology*
  • Cilia / ultrastructure
  • Fetus
  • Fluorescent Dyes
  • Hair Cells, Auditory / embryology*
  • Hair Cells, Auditory / physiology*
  • Hair Cells, Auditory / ultrastructure
  • Hearing / physiology*
  • Ion Channels / physiology
  • Ion Channels / ultrastructure
  • Mechanotransduction, Cellular / physiology*
  • Membrane Potentials / physiology
  • Mice
  • Microscopy, Electron, Scanning
  • Models, Neurological
  • Molecular Motor Proteins / physiology
  • Myosin Type I
  • Myosins / metabolism

Substances

  • Fluorescent Dyes
  • Ion Channels
  • Molecular Motor Proteins
  • Myosin Type I
  • MYO1C protein, human
  • Myosins