Abstract
Folate deficiency appears to play a crucial role early in cervical carcinogenesis by facilitating the incorporation of HPV genomes at a fragile chromosomal site. Thereafter, multiple nutritional, hormonal, and immunologic factors probably interact in a synergistic manner to determine whether the cell line becomes immortalized and invasive.
MeSH terms
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Female
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Folic Acid / metabolism*
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Folic Acid Deficiency / physiopathology*
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Genes, Tumor Suppressor
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Humans
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Oncogenes
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Papillomaviridae / genetics
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Risk Factors
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Uterine Cervical Dysplasia / microbiology
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Uterine Cervical Neoplasms / epidemiology*
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Uterine Cervical Neoplasms / etiology*
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Uterine Cervical Neoplasms / genetics
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Uterine Cervical Neoplasms / microbiology