The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1

Genomics. 1992 Dec;14(4):1089-91. doi: 10.1016/s0888-7543(05)80134-x.

Abstract

Cchl1a3 encodes the dihydropyridine-sensitive calcium channel alpha 1 subunit isoform predominantly expressed in skeletal muscle. mdg (muscular dysgenesis) has previously been implicated as a mutant allele of this gene. Hybridization of a rat brain cDNA probe for Cchl1a3 to Southern blots of DNAs from a panel of Chinese hamster x mouse somatic cell hybrids suggested that this gene maps to mouse Chromosome 1. Analysis of the progeny of an inbred strain cross-positioned Cchl1a3 1.3 cM proximal to the Pep-3 locus on Chr 1.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Calcium Channels / drug effects
  • Calcium Channels / genetics*
  • Chromosome Mapping*
  • Cricetinae
  • DNA
  • DNA Probes
  • Dihydropyridines / pharmacology*
  • Female
  • Haplotypes
  • Hybrid Cells
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Muscles / chemistry*

Substances

  • Calcium Channels
  • DNA Probes
  • Dihydropyridines
  • 1,4-dihydropyridine
  • DNA

Associated data

  • GENBANK/L04150
  • GENBANK/L04151
  • GENBANK/L04684
  • GENBANK/M88363
  • GENBANK/M88364
  • GENBANK/M88365
  • GENBANK/M88366
  • GENBANK/M90549
  • GENBANK/M90550
  • GENBANK/M90551