Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

C Troelstra; R M Landsvater; J Wiegant; M van der Ploeg; G Viel; C H Buys; J H Hoeijmakers

doi:10.1016/0888-7543(92)90304-b

Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

Genomics. 1992 Apr;12(4):745-9. doi: 10.1016/0888-7543(92)90304-b.

Authors

C Troelstra¹, R M Landsvater, J Wiegant, M van der Ploeg, G Viel, C H Buys, J H Hoeijmakers

Affiliation

¹ Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands.

PMID: 1349298
DOI: 10.1016/0888-7543(92)90304-b

Abstract

We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CHO Cells
Chromosome Mapping
Chromosomes, Human, Pair 10*
Cricetinae
DNA Repair / genetics*
DNA Repair / radiation effects
Female
Genetic Linkage
Humans
Hybrid Cells
Male
Mutation
Pedigree
Polymorphism, Restriction Fragment Length
Restriction Mapping
Ultraviolet Rays