Use of beta (beta)-adrenergic blocking agents began in the 1960s and has risen dramatically since then. Newer agents offer more actions and fewer side effects. Uses for the drugs continue to increase as their safety and efficacy become increasingly apparent. beta block, today, has widespread application in cardiovascular disease. In addition, these agents are used in the management of endocrine disorders, neurologic situations, psychiatric disorders, gastrointestinal problems, and sensory disorders. Many new beta blockers are still investigational, and some show even greater promise for therapeutic applications in the future.