Abstract
The abilities of FK506 and rapamycin to block distinct signal transduction pathways are mediated by soluble binding proteins. Previously, a family of these receptors has been recognized that includes a 25 kDa protein, FKBP25. We now report the isolation of a cDNA for FKBP25 from a human hippocampal cDNA library by oligonucleotide screening. The nucleotide sequence reveals an open reading frame that encodes a 224 amino acid polypeptide. Human FKBP25 shows 97% amino acid identity with bovine FKBP25 and 62% homology with human FKBP12.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Carrier Proteins / genetics*
-
Carrier Proteins / metabolism
-
Cattle
-
Cloning, Molecular
-
Gene Library
-
Humans
-
Immunosuppressive Agents / metabolism
-
Molecular Sequence Data
-
Molecular Weight
-
Oligodeoxyribonucleotides
-
Oligonucleotide Probes
-
Open Reading Frames
-
Polyenes / metabolism*
-
Sequence Homology, Nucleic Acid
-
Sirolimus
-
Tacrolimus / metabolism*
-
Tacrolimus Binding Proteins
Substances
-
Carrier Proteins
-
Immunosuppressive Agents
-
Oligodeoxyribonucleotides
-
Oligonucleotide Probes
-
Polyenes
-
Tacrolimus Binding Proteins
-
Sirolimus
-
Tacrolimus
Associated data
-
GENBANK/D10556
-
GENBANK/M90309
-
GENBANK/M97582
-
GENBANK/M97583
-
GENBANK/M97584
-
GENBANK/M97585
-
GENBANK/M97586
-
GENBANK/M97587
-
GENBANK/M97588
-
GENBANK/M97589