HLA antigens in Tlingit Indians with rheumatoid arthritis

Tissue Antigens. 1992 Aug;40(2):57-63. doi: 10.1111/j.1399-0039.1992.tb01960.x.

Abstract

HLA-DR4 has been described in association with rheumatoid arthritis (RA) in multiple populations. We have studied HLA antigens in Alaskan Tlingit Indians. HLA-DR4 was decreased in the RA group (n = 32) compared with controls (n = 62) (6% vs 21% p = 0.07). The predominant DR4 allele observed was DRB1*0403 (Dw13.1). The most striking observation in these studies was a marked predominance of the DRB1*1402 allele encoding Dw16 (DRw14). This allele was present in 91% of RA cases, but was also highly prevalent in controls (80%, OR = 2.4 p = 0.20). DRB1*1402 only was observed in 47% of cases and 31% of controls. The DRB3*0101 (DRw52), and the DQA*0501 and DQB*0301 alleles encoding a subset of DQw3 were associated with DRB1*1402 in cases and in controls. HLA-Bw62 was increased in RA cases (28%) compared with controls (8%) (OR = 4.5, p = 0.01, corrected p = ns).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Alaska
  • Alleles
  • Arthritis, Rheumatoid / epidemiology
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology*
  • DNA / genetics
  • Female
  • HLA Antigens / analysis*
  • HLA Antigens / genetics
  • HLA Antigens / immunology
  • HLA-A Antigens / analysis
  • HLA-A Antigens / genetics
  • HLA-B Antigens / analysis
  • HLA-B Antigens / genetics
  • HLA-C Antigens / genetics
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • Humans
  • Indians, North American / genetics*
  • Male
  • Middle Aged
  • Oligonucleotide Probes
  • Prevalence
  • Statistics as Topic

Substances

  • HLA Antigens
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Oligonucleotide Probes
  • DNA