Abstract
A novel, simple approach to retrospective assessment of "blindability" was applied to data on outpatients in a controlled, double-blind clinical comparison of a putative antidepressant, etoperidone, and placebo. A "blind" evaluator proved capable of discriminating between the active drug and placebo on the basis of reported side effects alone, raising questions about the true blindness of the study.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Ambulatory Care
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Antidepressive Agents / adverse effects*
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Antidepressive Agents / therapeutic use
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Bias
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Clinical Trials as Topic / standards*
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Depressive Disorder / drug therapy
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Double-Blind Method*
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Humans
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Placebos
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Retrospective Studies
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Trazodone / adverse effects
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Trazodone / analogs & derivatives*
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Trazodone / therapeutic use
Substances
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Antidepressive Agents
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Placebos
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etoperidone
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Trazodone