Abstract
Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, delta-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB1 antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Analysis of Variance
-
Animals
-
Antiemetics / pharmacology*
-
Avoidance Learning / drug effects*
-
Cannabidiol / pharmacology
-
Cannabinoid Receptor Agonists
-
Cannabinoid Receptor Antagonists
-
Cannabinoids / agonists
-
Cannabinoids / antagonists & inhibitors
-
Cannabinoids / pharmacology*
-
Conditioning, Classical / drug effects*
-
Dronabinol / analogs & derivatives*
-
Dronabinol / pharmacology
-
Drug Interactions
-
Lithium
-
Male
-
Nausea / chemically induced
-
Nausea / drug therapy
-
Nausea / physiopathology
-
Piperidines / pharmacology
-
Pyrazoles / pharmacology
-
Rats
-
Rats, Sprague-Dawley
-
Receptors, Cannabinoid / physiology
-
Rimonabant
-
Taste*
Substances
-
Antiemetics
-
Cannabinoid Receptor Agonists
-
Cannabinoid Receptor Antagonists
-
Cannabinoids
-
Piperidines
-
Pyrazoles
-
Receptors, Cannabinoid
-
Cannabidiol
-
3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran-1-ol
-
Dronabinol
-
Lithium
-
HU 211
-
Rimonabant