The effects of ante- and postnatal hypoxia on the central nervous system and their correction with peptide hormones

Neurosci Behav Physiol. 2003 Jul;33(6):607-11. doi: 10.1023/a:1023938905744.

Abstract

Ante- and postnatal hypoxia significantly worsened the postnatal development of animals. The posthypoxic behavioral model included hyperactivity and decreased learning ability, these being typical manifestations of attention deficit disorder. A peptide constellation prevented and significantly improved posthypoxic postnatal development and eliminated the majority of negative behavioral changes.

Publication types

  • Review

MeSH terms

  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Adrenocorticotropic Hormone / metabolism
  • Animals
  • Brain / embryology*
  • Brain / growth & development
  • Brain / metabolism*
  • Drug Therapy, Combination
  • Endorphins / administration & dosage
  • Endorphins / metabolism
  • Female
  • Humans
  • Hypoxia / embryology*
  • Hypoxia / metabolism*
  • Hypoxia / prevention & control
  • Neuroprotective Agents / administration & dosage*
  • Neuroprotective Agents / metabolism*
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / metabolism
  • Pregnancy
  • Pregnancy Complications / metabolism
  • Prenatal Exposure Delayed Effects*
  • Rats
  • Thyrotropin-Releasing Hormone / administration & dosage
  • Thyrotropin-Releasing Hormone / metabolism

Substances

  • Endorphins
  • Neuroprotective Agents
  • Peptide Fragments
  • Thyrotropin-Releasing Hormone
  • beta-casomorphin 7
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone