Abstract
Ante- and postnatal hypoxia significantly worsened the postnatal development of animals. The posthypoxic behavioral model included hyperactivity and decreased learning ability, these being typical manifestations of attention deficit disorder. A peptide constellation prevented and significantly improved posthypoxic postnatal development and eliminated the majority of negative behavioral changes.
MeSH terms
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Adrenocorticotropic Hormone / analogs & derivatives*
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Adrenocorticotropic Hormone / metabolism
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Animals
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Brain / embryology*
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Brain / growth & development
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Brain / metabolism*
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Drug Therapy, Combination
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Endorphins / administration & dosage
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Endorphins / metabolism
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Female
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Humans
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Hypoxia / embryology*
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Hypoxia / metabolism*
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Hypoxia / prevention & control
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Neuroprotective Agents / administration & dosage*
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Neuroprotective Agents / metabolism*
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Peptide Fragments / administration & dosage
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Peptide Fragments / metabolism
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Pregnancy
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Pregnancy Complications / metabolism
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Prenatal Exposure Delayed Effects*
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Rats
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Thyrotropin-Releasing Hormone / administration & dosage
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Thyrotropin-Releasing Hormone / metabolism
Substances
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Endorphins
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Neuroprotective Agents
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Peptide Fragments
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Thyrotropin-Releasing Hormone
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beta-casomorphin 7
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ACTH (4-7), Pro-Gly-Pro-
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Adrenocorticotropic Hormone