Abstract
Death receptors [Fas/Apo-1/CD95, TNF-R1 [tumour necrosis factor (TNF) receptor 1], DR3 [death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2, DR6, p75-NGFR [p75-nerve growth factor receptor], EDAR [ectodermal dysplasia receptor]] form a subgroup of the TNF-R superfamily that can induce apoptosis (programmed cell death) via a conserved cytoplasmic signalling module termed the death domain. Although death receptors have been recognized mainly as apoptosis inducers, there is growing evidence that these receptors also fulfil a variety of nonapoptotic functions. This review is focused on the molecular mechanisms of apoptotic and non-apoptotic death receptor signalling in light of the phenotype of mice deficient in the various death receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis*
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Edar Receptor
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Membrane Proteins / metabolism
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Mice
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Models, Biological
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Receptor, Nerve Growth Factor / metabolism
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Receptors, Ectodysplasin
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor / metabolism
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Receptors, Tumor Necrosis Factor, Member 25
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Signal Transduction
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fas Receptor / metabolism
Substances
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EDAR protein, human
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Edar Receptor
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Edar protein, mouse
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Membrane Proteins
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Receptor, Nerve Growth Factor
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Receptors, Ectodysplasin
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Member 25
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TNFRSF10A protein, human
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TNFRSF10B protein, human
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TNFRSF25 protein, human
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Tnfrsf10b protein, mouse
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Tnfrsf21 protein, mouse
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Tnfrsf25 protein, mouse
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fas Receptor