The role of protein elongation factor eEF1A2 in ovarian cancer

Reprod Biol Endocrinol. 2003 Oct 7:1:69. doi: 10.1186/1477-7827-1-69.

Abstract

Frequent gains of chromosome 20q12-13 in ovarian tumors indicate that at least one important oncogene is found at that locus. One of the genes there is EEF1A2, which maps to 20q13.3 and encodes protein elongation factor eEF1A2. This review will focus on recent evidence indicating that EEF1A2 is an important ovarian oncogene and that the protein elongation network can activate tumorigenesis and inhibit apoptosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / genetics
  • Cell Transformation, Neoplastic / genetics
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 20 / genetics
  • Chromosomes, Human, Pair 20 / ultrastructure
  • Female
  • Gene Amplification
  • Humans
  • In Situ Hybridization, Fluorescence
  • Nucleic Acid Hybridization
  • Oncogenes
  • Ovarian Neoplasms / etiology
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Peptide Chain Elongation, Translational
  • Peptide Elongation Factor 1 / genetics
  • Peptide Elongation Factor 1 / physiology*
  • Trisomy

Substances

  • EEF1A2 protein, human
  • Peptide Elongation Factor 1