5-HT6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

Synapse. 2004 Feb;51(2):158-64. doi: 10.1002/syn.10288.

Abstract

The present study investigated the neurochemical effects of the selective 5-HT(6) receptor antagonist SB-271046 in the rat medial prefrontal cortex (mPFC). The effect of SB-271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. SB-271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5-HT neurotransmission. These results further support the rationale for the use of 5-HT(6) receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • Biogenic Monoamines / metabolism*
  • Brain Chemistry
  • Chromatography, High Pressure Liquid
  • Dose-Response Relationship, Drug
  • Extracellular Space / drug effects*
  • Male
  • Microdialysis / methods
  • Prefrontal Cortex / drug effects*
  • Prefrontal Cortex / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Serotonin / metabolism
  • Serotonin Antagonists / pharmacology*
  • Sulfonamides / pharmacology*
  • Thiophenes / pharmacology*
  • Time Factors

Substances

  • Biogenic Monoamines
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Sulfonamides
  • Thiophenes
  • serotonin 6 receptor
  • SB 271046