Anticholinesterase mechanism as a factor of immunotoxicity of various chemical compounds

Bull Exp Biol Med. 2003 Aug;136(2):176-8. doi: 10.1023/a:1026327225739.

Abstract

Experiments on Wistar rats showed that acute poisoning with chemicals in a dose of 0.75 LD(50) (dimethyl dichlorovinyl phosphate, sarin, VX substance, sulfur yperite, lewisite, tetraethyl lead, dichloroethane) inhibiting platelet acetylcholine esterase, alpha-naphthyl-AS-acetate esterase, and alpha-naphthyl-butyrate esterase suppressed T cell-mediated immune reactions.

MeSH terms

  • Animals
  • Cholinesterase Inhibitors / immunology
  • Cholinesterase Inhibitors / metabolism*
  • Cholinesterase Inhibitors / toxicity
  • Enzyme Inhibitors / metabolism
  • Esterases / antagonists & inhibitors
  • Esterases / metabolism
  • Immune System / physiology
  • Immunotoxins / metabolism*
  • Male
  • Rats
  • Rats, Wistar
  • Spleen / cytology
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology

Substances

  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Immunotoxins
  • Esterases