Enigmatic variations: divergent modes of regulating eukaryotic DNA replication

Mol Cell. 2003 Nov;12(5):1067-75. doi: 10.1016/s1097-2765(03)00441-6.

Abstract

Proteins involved in DNA replication are conserved from yeast to mammals, suggesting that the mechanism was established at an early stage of eukaryotic evolution. In spite of this common origin, recent findings have revealed surprising variations in how replication initiation is controlled, implying that a conserved mechanism has not necessarily resulted in regulatory conservation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Cycle Proteins / metabolism
  • DNA / genetics
  • DNA / metabolism
  • DNA Helicases / metabolism
  • DNA Replication*
  • DNA, Fungal / genetics
  • DNA, Fungal / metabolism
  • DNA-Binding Proteins / metabolism
  • Eukaryotic Cells / physiology*
  • Origin Recognition Complex

Substances

  • Cell Cycle Proteins
  • DNA, Fungal
  • DNA-Binding Proteins
  • Origin Recognition Complex
  • DNA
  • DNA Helicases