Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil

J Dermatol. 2003 Oct;30(10):730-4. doi: 10.1111/j.1346-8138.2003.tb00468.x.

Abstract

A case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described. The patient was successfully treated with a combination of acitretin and intralesional 5-fluorouracil. All the lesions resolved after three months of therapy with no side effects and no recurrence during four months of follow-up.

Publication types

  • Case Reports

MeSH terms

  • Acitretin / administration & dosage*
  • Arsenic / adverse effects*
  • Biopsy, Needle
  • Bowen's Disease / complications
  • Bowen's Disease / drug therapy*
  • Bowen's Disease / pathology
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / pathology
  • Drug Therapy, Combination
  • Fluorouracil / administration & dosage*
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • India
  • Injections, Intralesional
  • Keratosis / chemically induced
  • Keratosis / complications
  • Keratosis / drug therapy*
  • Keratosis / pathology
  • Male
  • Middle Aged
  • Precancerous Conditions / chemically induced
  • Precancerous Conditions / drug therapy
  • Precancerous Conditions / pathology
  • Skin Neoplasms / complications
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Treatment Outcome
  • Water Pollutants / adverse effects

Substances

  • Water Pollutants
  • Acitretin
  • Arsenic
  • Fluorouracil