The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

J Clin Invest. 2004 Jan;113(1):25-7. doi: 10.1172/JCI20660.

Abstract

IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. A new study (see the related article beginning on page 96) shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Growth Hormone / pharmacology
  • Growth Hormone / physiology
  • Human Growth Hormone / physiology*
  • Insulin / pharmacology*
  • Insulin / physiology*
  • Insulin-Like Growth Factor I / deficiency
  • Insulin-Like Growth Factor I / physiology*
  • Mice
  • Mice, Knockout

Substances

  • Insulin
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • Growth Hormone