Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats

Pol J Pharmacol. 2003 Nov-Dec;55(6):1149-52.

Abstract

The obtained results show that DTG, the sigma1/sigma2 receptor agonist, exerts a synergistic effect with memantine, an uncompetitive NMDA receptor antagonist, in the forced swimming test in rats, and that progesterone and BD 1047, the sigma1 receptor antagonists, counteract this effect. The results suggest that the sigma1 receptor subtype may contribute to the behavioral response induced by combined administration of DTG and memantine in Porsolt's test in rats.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Guanidines / administration & dosage
  • Guanidines / pharmacology*
  • Male
  • Memantine / administration & dosage
  • Memantine / pharmacology*
  • Motor Activity / drug effects*
  • Progesterone / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, sigma / antagonists & inhibitors*
  • Receptors, sigma / physiology
  • Sigma-1 Receptor
  • Swimming

Substances

  • Antidepressive Agents
  • Guanidines
  • Receptors, sigma
  • sigma-2 receptor
  • Progesterone
  • 1,3-ditolylguanidine
  • Memantine