Is there a role for GPIs in yeast cell-wall assembly?

H de Nobel; P N Lipke

doi:10.1016/0962-8924(94)90003-5

Is there a role for GPIs in yeast cell-wall assembly?

Trends Cell Biol. 1994 Feb;4(2):42-5. doi: 10.1016/0962-8924(94)90003-5.

Authors

H de Nobel¹, P N Lipke

Affiliation

¹ Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405, USA.

PMID: 14731865
DOI: 10.1016/0962-8924(94)90003-5

Abstract

Glycosylphosphatidylinositol (GPI) membrane anchors are essential for the integration of yeast cell adhesion proteins into the cell wall, but mature cell-wall proteins are unlikely to be attached directly to the membrane. We thus propose that GPI-anchored glycoprotein forms are intermediates in a process that crosslinks the major components of the cell wall by transglycosylation. This mechanism may be critical for both the biosynthesis and overall architecture of the cell wall.