A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications

Yoshihito Okada; Akiko Ishimaru; Ryuichiro Suzuki; Toru Okuyama

doi:10.1021/np030323j

A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications

J Nat Prod. 2004 Jan;67(1):103-5. doi: 10.1021/np030323j.

Authors

Yoshihito Okada¹, Akiko Ishimaru, Ryuichiro Suzuki, Toru Okuyama

Affiliation

¹ Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.

PMID: 14738398
DOI: 10.1021/np030323j

Abstract

A new phloroglucinol derivative (1) and two known compounds (2 and 3) were isolated from the brown alga Eisenia bicyclis. These isolates exhibit inhibitory activity on glycation and alpha-amylase. Their structures were determined on the basis of spectroscopic data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus / drug therapy*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology
Glycation End Products, Advanced / antagonists & inhibitors
Japan
Molecular Structure
Phaeophyceae / chemistry*
Phloroglucinol* / analogs & derivatives
Phloroglucinol* / chemistry
Phloroglucinol* / isolation & purification
Phloroglucinol* / pharmacology
alpha-Amylases / antagonists & inhibitors

Substances

Enzyme Inhibitors
Glycation End Products, Advanced
Phloroglucinol
alpha-Amylases