Abstract
The heterodimeric nuclease Mus81-Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossover formation may not always involve double Holliday junctions.
MeSH terms
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Crossing Over, Genetic / genetics*
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DNA Damage / genetics
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DNA Damage / physiology
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DNA Repair / genetics
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DNA Repair / physiology
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Endonucleases*
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Holliday Junction Resolvases / genetics*
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Meiosis / genetics
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Meiosis / physiology*
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Models, Genetic*
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces
Substances
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DNA-Binding Proteins
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Saccharomyces cerevisiae Proteins
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Endonucleases
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MUS81 protein, S cerevisiae
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Holliday Junction Resolvases