Dominant genes for colorectal cancer are not rare

R S Houlston; A Collins; J Slack; N E Morton

doi:10.1111/j.1469-1809.1992.tb01136.x

Dominant genes for colorectal cancer are not rare

Ann Hum Genet. 1992 May;56(2):99-103. doi: 10.1111/j.1469-1809.1992.tb01136.x.

Authors

R S Houlston¹, A Collins, J Slack, N E Morton

Affiliation

¹ Department of Community Medicine, Southampton General Hospital.

PMID: 1503398
DOI: 10.1111/j.1469-1809.1992.tb01136.x

Abstract

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Colorectal Neoplasms / genetics*
Female
Gene Frequency
Genes, Dominant*
Humans
Male
Middle Aged
Pedigree