Asymmetric autocatalysis and its implications for the origin of homochirality

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5732-6. doi: 10.1073/pnas.0308363101. Epub 2004 Apr 5.

Abstract

An autocatalytic reaction in which the reaction product serves as a catalyst to produce more of itself and to suppress production of its enantiomer serves as a mechanistic model for the evolution of homochirality. The Soai reaction provided experimental confirmation of this concept, nearly 50 years after it was first proposed. This Perspective offers a rationalization of the Soai autocatalytic reaction; accounting for enantiomeric excess and rate observations, that is both simple as well as gratifying in its implications for the chemical origin of life.