Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia

Giuliana Giribaldi; Daniela Ulliers; Evelin Schwarzer; Irene Roberts; Wanda Piacibello; Paolo Arese

Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia

Haematologica. 2004 Apr;89(4):492-3.

Authors

Giuliana Giribaldi, Daniela Ulliers, Evelin Schwarzer, Irene Roberts, Wanda Piacibello, Paolo Arese

PMID: 15075084

Abstract

Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progenitor growth.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / pharmacology*
Anemia / etiology*
Animals
Cells, Cultured
Erythropoiesis / drug effects*
Hemeproteins / pharmacology*
Humans
Malaria / blood*
Plasmodium / chemistry
Plasmodium / pathogenicity

Substances

Aldehydes
Hemeproteins
hemozoin
4-hydroxy-2-nonenal