Abstract
The COPII vesicle coat coordinates the budding of transport vesicles from the endoplasmic reticulum in the initial step of the secretory pathway. The coat orchestrates a sequence of events including self-assembly on the membrane, cargo and SNARE molecule selection, and deformation of the membrane into a bud to drive vesicle fission. Recent molecular-level studies have helped to explain how the three components of yeast COPII - Sar1 GTPase, the Sec23/24 subcomplex and the Sec13/31 subcomplex - combine to organize this complex process.
MeSH terms
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COP-Coated Vesicles / metabolism*
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Carrier Proteins / metabolism
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GTPase-Activating Proteins
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Golgi Apparatus / metabolism
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Guanosine Triphosphate / metabolism
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Membrane Proteins / metabolism*
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Models, Molecular*
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Monomeric GTP-Binding Proteins / metabolism
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Nuclear Pore Complex Proteins
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Phosphoproteins / metabolism
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Protein Transport / physiology
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Saccharomyces cerevisiae
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Saccharomyces cerevisiae Proteins / metabolism*
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Vesicular Transport Proteins
Substances
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Carrier Proteins
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GTPase-Activating Proteins
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Membrane Proteins
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Nuclear Pore Complex Proteins
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Phosphoproteins
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SEC13 protein, S cerevisiae
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SEC23 protein, S cerevisiae
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SEC24 protein, S cerevisiae
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SEC31 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Vesicular Transport Proteins
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Guanosine Triphosphate
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Monomeric GTP-Binding Proteins
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SAR1 protein, S cerevisiae