Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccines

Xuan-Yi Wang; Zhiyi Xu; Xing Yao; Meiying Tian; Liangdi Zhou; Lifang He; Yumei Wen

doi:10.1016/j.vaccine.2003.11.007

Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccines

Vaccine. 2004 May 7;22(15-16):1941-5. doi: 10.1016/j.vaccine.2003.11.007.

Authors

Xuan-Yi Wang¹, Zhiyi Xu, Xing Yao, Meiying Tian, Liangdi Zhou, Lifang He, Yumei Wen

Affiliation

¹ Department of Medical Molecular Virology, 138 Yi Xue Yuan Road, Shanghai Medical College, Fudan University, Shanghai 200032, China.

PMID: 15121306
DOI: 10.1016/j.vaccine.2003.11.007

Abstract

The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared. Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12 and 24, and the anti-HAV total IgG antibody and IgG subclass profile were assessed. In both vaccinated groups, the geometric mean titer (GMT) of anti-HAV peaked 7 months after the initial dose and declined during the following months. The IgG subclass profiles in both vaccinated groups were highly restricted to IgG1 and IgG3. Both vaccines have been shown highly effective in preventing viral hepatitis A in former studies.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Child
Child, Preschool
Female
Hepatitis A Antibodies / analysis
Hepatitis A Antibodies / biosynthesis*
Hepatitis A Vaccines / immunology*
Humans
Immunoglobulin G / biosynthesis
Immunoglobulin G / genetics
Male
Vaccines, Attenuated / immunology
Vaccines, Inactivated / immunology

Substances

Hepatitis A Antibodies
Hepatitis A Vaccines
Immunoglobulin G
Vaccines, Attenuated
Vaccines, Inactivated