Abstract
Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acetyltransferases / metabolism
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Animals
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Cell Cycle Proteins / chemistry
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Cell Cycle Proteins / classification
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Cell Cycle Proteins / metabolism*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / classification
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DNA-Binding Proteins / metabolism*
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E2F Transcription Factors
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Gene Silencing*
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Histone Acetyltransferases
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Histone Deacetylases / metabolism
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Humans
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Repressor Proteins / metabolism*
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Retinoblastoma Protein / metabolism*
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Transcription Factors / chemistry
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Transcription Factors / classification
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Transcription Factors / metabolism*
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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E2F Transcription Factors
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Repressor Proteins
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Retinoblastoma Protein
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Transcription Factors
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Acetyltransferases
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Histone Acetyltransferases
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Histone Deacetylases