Abstract
The discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Active Transport, Cell Nucleus / genetics
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Active Transport, Cell Nucleus / physiology*
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Animals
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Cell Nucleus / genetics
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Cell Nucleus / metabolism*
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Humans
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Karyopherins / genetics
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Karyopherins / metabolism*
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MicroRNAs / genetics
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MicroRNAs / metabolism*
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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beta Karyopherins / genetics
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beta Karyopherins / metabolism*
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ran GTP-Binding Protein / genetics
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ran GTP-Binding Protein / metabolism*
Substances
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Karyopherins
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MicroRNAs
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Nuclear Proteins
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XPO5 protein, human
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beta Karyopherins
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ran GTP-Binding Protein