MicroRNA precursors in motion: exportin-5 mediates their nuclear export

Trends Cell Biol. 2004 Apr;14(4):156-9. doi: 10.1016/j.tcb.2004.02.006.

Abstract

The discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / genetics
  • Active Transport, Cell Nucleus / physiology*
  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Humans
  • Karyopherins / genetics
  • Karyopherins / metabolism*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • beta Karyopherins / genetics
  • beta Karyopherins / metabolism*
  • ran GTP-Binding Protein / genetics
  • ran GTP-Binding Protein / metabolism*

Substances

  • Karyopherins
  • MicroRNAs
  • Nuclear Proteins
  • XPO5 protein, human
  • beta Karyopherins
  • ran GTP-Binding Protein