The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

Tobias von der Haar; John D Gross; Gerhard Wagner; John E G McCarthy

doi:10.1038/nsmb779

The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

Nat Struct Mol Biol. 2004 Jun;11(6):503-11. doi: 10.1038/nsmb779.

Authors

Tobias von der Haar¹, John D Gross, Gerhard Wagner, John E G McCarthy

Affiliation

¹ Post-transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK. Tobias.von-der-Haar@umist.ac.uk

PMID: 15164008
DOI: 10.1038/nsmb779

Abstract

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Active Transport, Cell Nucleus
Eukaryotic Initiation Factor-4E / chemistry
Eukaryotic Initiation Factor-4E / metabolism
Eukaryotic Initiation Factor-4E / physiology*
Gene Expression Regulation*
Protein Binding
Protein Biosynthesis
RNA Cap-Binding Proteins / chemistry
RNA Cap-Binding Proteins / metabolism
RNA Cap-Binding Proteins / physiology*
RNA Stability

Substances

Eukaryotic Initiation Factor-4E
RNA Cap-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding