Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

Org Lett. 2004 Jun 10;6(12):1951-4. doi: 10.1021/ol049503q.

Abstract

[structure: see text] Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Coumarins
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Conformation
  • Porifera / chemistry*
  • Pyrans* / chemistry*
  • Pyrans* / pharmacology
  • Pyrones* / chemistry
  • Pyrones* / pharmacology
  • Stereoisomerism

Substances

  • Coumarins
  • Pyrans
  • Pyrones
  • psymberin
  • pederin