Abstract
[structure: see text] Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Survival / drug effects
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Coumarins
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Drug Screening Assays, Antitumor
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Humans
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Molecular Conformation
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Porifera / chemistry*
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Pyrans* / chemistry*
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Pyrans* / pharmacology
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Pyrones* / chemistry
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Pyrones* / pharmacology
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Stereoisomerism
Substances
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Coumarins
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Pyrans
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Pyrones
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psymberin
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pederin