Abstract
This review summarizes the mechanisms of neurotoxicity associated to androgen receptor containing an elongated polyglutamine tract responsible for motor neuronal cell death.
Copyright 2004 Elsevier Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain Stem / cytology
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Brain Stem / metabolism*
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Cell Death / physiology
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Humans
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Male
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Motor Neurons / chemistry
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Motor Neurons / metabolism*
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Muscular Disorders, Atrophic / metabolism*
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Mutation
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Neurotoxins / genetics
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Neurotoxins / metabolism
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Peptides / genetics
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Peptides / metabolism*
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Receptors, Androgen / genetics
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Receptors, Androgen / metabolism*
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Spinal Cord / cytology
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Spinal Cord / metabolism*
Substances
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Neurotoxins
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Peptides
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Receptors, Androgen
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polyglutamine