Fruit ripening is a unique aspect of plant development with direct implications for a large component of the food supply and related areas of human health and nutrition. Recent advances in ripening research have given insights into the molecular basis of conserved developmental signals coordinating the ripening process and suggest that sequences related to floral development genes might be logical targets for additional discovery. Recent characterization of hormonal and environmental signal transduction components active in tomato fruit ripening (particularly ethylene and light) show conservation of signaling components yet novel gene family size and expression motifs that might facilitate complete and timely manifestation of ripening phenotypes. Emerging genomics tools and approaches are rapidly providing new clues and candidate genes that are expanding the known regulatory circuitry of ripening.