BINAP/1,4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues

Takeshi Ohkuma; Tomonori Hattori; Hirohito Ooka; Tsutomu Inoue; Ryoji Noyori

doi:10.1021/ol049157c

BINAP/1,4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues

Org Lett. 2004 Aug 5;6(16):2681-3. doi: 10.1021/ol049157c.

Authors

Takeshi Ohkuma¹, Tomonori Hattori, Hirohito Ooka, Tsutomu Inoue, Ryoji Noyori

Affiliation

¹ Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan..

PMID: 15281743
DOI: 10.1021/ol049157c

Abstract

A combined system of a RuCl(2)(binap)(1,4-diamine) complex and t-C(4)H(9)OK in i-C(3)H(7)OH catalyzes enantioselective hydrogenation of various 1-tetralone derivatives and some methylated 2-cyclohexenones. Hydrogenation of 2-methyl-1-tetralone under dynamic kinetic resolution gives the cis alcohol with high ee. [reaction: see text]