Abstract
The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.
MeSH terms
-
Animals
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / metabolism*
-
Humans
-
Hydroxylation
-
Hypoxia-Inducible Factor 1
-
Hypoxia-Inducible Factor 1, alpha Subunit
-
Nuclear Proteins / genetics
-
Nuclear Proteins / metabolism*
-
Oxygen / metabolism*
-
Signal Transduction / physiology*
-
Transcription Factors*
Substances
-
DNA-Binding Proteins
-
HIF1A protein, human
-
Hypoxia-Inducible Factor 1
-
Hypoxia-Inducible Factor 1, alpha Subunit
-
Nuclear Proteins
-
Transcription Factors
-
Oxygen