Abstract
The alpha 5 beta 1, alpha 6 beta 4 and Mac-1 integrins all participate in the endocytotic cycle. By contrast, alpha 3 beta 1, alpha 4 beta 1 and LFA-1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha-chains appear to determine whether an integrin cycles or not, and that alpha 5 beta 1, alpha 6 beta 4 and Mac-1 can be brought to the leading edge of a moving cell by endocytosis and recycling.
MeSH terms
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Animals
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CHO Cells
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Cell Line
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Cricetinae
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Endocytosis
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Fibronectins / physiology
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Humans
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Integrins / analysis
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Integrins / physiology*
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Lymphocyte Function-Associated Antigen-1 / analysis
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Macrophage-1 Antigen / analysis
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Macrophage-1 Antigen / physiology*
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Macrophages / physiology*
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Mice
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Receptors, Fibronectin
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Receptors, Immunologic / analysis
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Receptors, Immunologic / physiology*
Substances
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Fibronectins
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Integrins
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Lymphocyte Function-Associated Antigen-1
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Macrophage-1 Antigen
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Receptors, Fibronectin
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Receptors, Immunologic