Abstract
Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant. In contrast, resistance to fusidic acid in a collection of nonepidemic strains resulted primarily from mutations in fusA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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DNA Primers
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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Europe / epidemiology
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Fusidic Acid / pharmacology*
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Genes, Bacterial / genetics
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Humans
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Impetigo / microbiology
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Microbial Sensitivity Tests
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Multigene Family
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Mutation / genetics
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Peptide Elongation Factor G / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Staphylococcal Infections / epidemiology
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA Primers
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DNA, Bacterial
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FusA protein, Staphylococcus aureus
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FusB protein, Staphylococcus aureus
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Peptide Elongation Factor G
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Fusidic Acid