A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates

Antimicrob Agents Chemother. 2004 Sep;48(9):3594-7. doi: 10.1128/AAC.48.9.3594-3597.2004.

Abstract

Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant. In contrast, resistance to fusidic acid in a collection of nonepidemic strains resulted primarily from mutations in fusA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • DNA Primers
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Europe / epidemiology
  • Fusidic Acid / pharmacology*
  • Genes, Bacterial / genetics
  • Humans
  • Impetigo / microbiology
  • Microbial Sensitivity Tests
  • Multigene Family
  • Mutation / genetics
  • Peptide Elongation Factor G / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Staphylococcal Infections / epidemiology
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA Primers
  • DNA, Bacterial
  • FusA protein, Staphylococcus aureus
  • FusB protein, Staphylococcus aureus
  • Peptide Elongation Factor G
  • Fusidic Acid