Abstract
Cocaine has anaesthetic, vasoconstrictive and CNS stimulatory effects. Presently, it is used clinically as a local anaesthetic and abused as a recreational drug. It has been implicated in both acute and chronic renal failure and has been reported to affect every aspect of the nephron. This article will review the spectrum of cocaine-induced kidney disease and attempt to give insight into the pathophysiological mechanisms involved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acute Kidney Injury / chemically induced
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Anesthetics, Local / adverse effects
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Animals
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Arteriosclerosis / chemically induced
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Cocaine / adverse effects*
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Cocaine / pharmacokinetics
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Cocaine / pharmacology
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Cocaine-Related Disorders / complications
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Corpus Striatum / drug effects
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Dopamine / physiology
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Dopamine Plasma Membrane Transport Proteins
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Female
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Humans
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Hypertension / chemically induced
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Infarction / chemically induced
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Kidney / blood supply
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Kidney / drug effects
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Kidney Diseases / chemically induced*
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Kidney Failure, Chronic / chemically induced
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Male
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Membrane Glycoproteins / antagonists & inhibitors
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Membrane Transport Modulators
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Membrane Transport Proteins / antagonists & inhibitors
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Middle Aged
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Nerve Tissue Proteins / antagonists & inhibitors
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Platelet Activation / drug effects
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Rats
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Rats, Wistar
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Renal Artery / drug effects
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Rhabdomyolysis / chemically induced
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Rhabdomyolysis / complications
Substances
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Anesthetics, Local
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Modulators
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Cocaine
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Dopamine