The pioneering use of systems analysis to study cardiac output regulation

Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1009-11. doi: 10.1152/classicessays.00007.2004.

Abstract

This essay examines the historical significance of an APS classic paper that is freely available online: Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955 (http://ajplegacy.physiology.org/cgi/reprint/180/3/463).

Publication types

  • Editorial
  • Historical Article

MeSH terms

  • Animals
  • Cardiac Output / physiology*
  • Cardiovascular Physiological Phenomena*
  • Dogs
  • Heart / physiology
  • History, 20th Century
  • Models, Biological
  • Physiology / history*