tRNA maturation: RNA polymerization without a nucleic acid template

Curr Biol. 2004 Oct 26;14(20):R883-5. doi: 10.1016/j.cub.2004.09.069.

Abstract

The CCA-adding enzyme, which builds and repairs the 3' terminal CCA sequence of tRNA, is the only RNA polymerase that can synthesize a defined nucleotide sequence without using a nucleic acid template. New cocrystal structures tell us how this remarkable enzyme works.

Publication types

  • Review

MeSH terms

  • Archaeoglobus fulgidus / genetics
  • Archaeoglobus fulgidus / metabolism
  • Bacteria / genetics
  • Bacteria / metabolism
  • Binding Sites / genetics
  • Models, Genetic*
  • RNA Nucleotidyltransferases / chemistry*
  • RNA Nucleotidyltransferases / genetics*
  • RNA Nucleotidyltransferases / metabolism
  • RNA, Transfer / genetics*
  • RNA, Transfer / metabolism

Substances

  • RNA, Transfer
  • RNA Nucleotidyltransferases
  • tRNA nucleotidyltransferase