Abstract
The CCA-adding enzyme, which builds and repairs the 3' terminal CCA sequence of tRNA, is the only RNA polymerase that can synthesize a defined nucleotide sequence without using a nucleic acid template. New cocrystal structures tell us how this remarkable enzyme works.
MeSH terms
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Archaeoglobus fulgidus / genetics
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Archaeoglobus fulgidus / metabolism
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Bacteria / genetics
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Bacteria / metabolism
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Binding Sites / genetics
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Models, Genetic*
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RNA Nucleotidyltransferases / chemistry*
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RNA Nucleotidyltransferases / genetics*
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RNA Nucleotidyltransferases / metabolism
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RNA, Transfer / genetics*
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RNA, Transfer / metabolism
Substances
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RNA, Transfer
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RNA Nucleotidyltransferases
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tRNA nucleotidyltransferase