Little lambda, who made thee?

Microbiol Mol Biol Rev. 2004 Dec;68(4):796-813. doi: 10.1128/MMBR.68.4.796-813.2004.

Abstract

The study of the bacteriophage lambda has been critical to the discipline of molecular biology. It was the source of key discoveries in the mechanisms of, among other processes, gene regulation, recombination, and transcription initiation and termination. We trace here the events surrounding these findings and draw on the recollections of the participants. We show how a particular atmosphere of interactions among creative scientists yielded spectacular insights into how living things work.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Bacteriophage lambda / genetics*
  • Bacteriophage lambda / metabolism
  • Endodeoxyribonucleases / metabolism
  • History, 20th Century
  • Prophages / genetics
  • Viral Regulatory and Accessory Proteins / metabolism
  • Virology / history
  • Virus Integration / genetics

Substances

  • N protein, Bacteriophage lambda
  • Viral Regulatory and Accessory Proteins
  • Endodeoxyribonucleases
  • terminase