The open-eyelid mutation, lidgap-Gates, is an eight-exon deletion in the mouse Map3k1 gene

Diana M Juriloff; Muriel J Harris; Diana G Mah

doi:10.1016/j.ygeno.2004.10.002

The open-eyelid mutation, lidgap-Gates, is an eight-exon deletion in the mouse Map3k1 gene

Genomics. 2005 Jan;85(1):139-42. doi: 10.1016/j.ygeno.2004.10.002.

Authors

Diana M Juriloff¹, Muriel J Harris, Diana G Mah

Affiliation

¹ Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3. juriloff@interchange.ubc.ca

PMID: 15607429
DOI: 10.1016/j.ygeno.2004.10.002

Abstract

The BALB/cGa mouse strain and its descendants, now called the SELH/Bc strain, have produced two waves of high frequency of spontaneous heritable mutations. One of these, the recessive lidgap-Gates (lg(Ga)) mutation, causes the same open-eyelids-at-birth phenotype as the gene knockout mutations of Map3k1 and co-maps to distal Chr 13. The lg(Ga) mutation is demonstrated to be a 27.5-kb deletion of exons 2-9 in the Map3k1 gene, the first spontaneous mutant allele described at this locus. The lg(Ga) mutation is consistent with a pattern suggesting that the waves of mutation in BALB/cGa and its descendants tend to be large deletions or ETn insertions, whose elevated rate of occurrence is due to an unknown mechanism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosomes / genetics
Exons / genetics*
Eyelids*
MAP Kinase Kinase Kinase 1 / genetics*
Mice
Mice, Mutant Strains
Mutagenesis, Insertional*
Sequence Deletion / genetics*

Substances

MAP Kinase Kinase Kinase 1