The purpose of this study was to compare the quality of life and health related variables in two groups of liver transplant patients, one at 2 years or less after transplant and the other at more than 2 years after transplant. Both groups reported a high overall quality of life and an above average health status. Long-term transplant patients reported significantly more health-related functional impairment and a tendency toward higher levels of depressed and anxious moods. The high quality of life suggested that patients were coping effectively with the realities of life, despite health-related functional impairment.