Are proteins made from a limited parts list?

Nicholas C Fitzkee; Patrick J Fleming; Haipeng Gong; Nicholas Panasik Jr; Timothy O Street; George D Rose

doi:10.1016/j.tibs.2004.12.005

Are proteins made from a limited parts list?

Trends Biochem Sci. 2005 Feb;30(2):73-80. doi: 10.1016/j.tibs.2004.12.005.

Authors

Nicholas C Fitzkee¹, Patrick J Fleming, Haipeng Gong, Nicholas Panasik Jr, Timothy O Street, George D Rose

Affiliation

¹ Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

PMID: 15691652
DOI: 10.1016/j.tibs.2004.12.005

Abstract

Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Hydrogen Bonding
Models, Molecular
Peptides / chemistry
Protein Conformation
Protein Folding*
Protein Structure, Secondary
Protein Structure, Tertiary
Proteins / chemistry*
Thermodynamics
Water / chemistry

Substances

Peptides
Proteins
Water
polyproline