Abstract
The spatial control of signalling events is critical in determining the outcome of a cellular response. Recent studies on the signal output from the growth factor/receptor HGF/c-Met, demonstrates that the PKC-regulated location of downstream transducers, specifically the MAPkinase ERK1/2, has a profound positive influence on cell migration, despite apparently reducing the steady state level of ERK1/2 activation. The mechanisms involved and the implications for signalling studies are discussed.
MeSH terms
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Animals
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Cell Cycle
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Cell Movement
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Cell Nucleus / metabolism
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Endosomes / metabolism
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Enzyme Activation
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Gene Expression Regulation, Neoplastic*
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Humans
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Integrins / metabolism
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MAP Kinase Signaling System
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Mitogen-Activated Protein Kinase 1 / metabolism
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Mitogen-Activated Protein Kinase 3 / metabolism
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Models, Biological
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Neoplasms / metabolism
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Protein Kinase C / metabolism
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Proto-Oncogene Proteins c-met / metabolism*
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Signal Transduction*
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Time Factors
Substances
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Integrins
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Proto-Oncogene Proteins c-met
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Protein Kinase C
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 3