Renin inhibition: what are the therapeutic opportunities?

Naomi D L Fisher; Norman K Hollenberg

doi:10.1681/ASN.2004100874

Renin inhibition: what are the therapeutic opportunities?

J Am Soc Nephrol. 2005 Mar;16(3):592-9. doi: 10.1681/ASN.2004100874. Epub 2005 Feb 9.

Authors

Naomi D L Fisher¹, Norman K Hollenberg

Affiliation

¹ Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

PMID: 15703270
DOI: 10.1681/ASN.2004100874

Abstract

Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has become a crucial element in cardiovascular and renal medicine. This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption.

Publication types

Review

MeSH terms

Dipeptides / therapeutic use*
Drug Design
Humans
Hypertension, Renal / drug therapy*
Peptides / chemistry
Peptides / therapeutic use
Piperazines / therapeutic use
Renin / antagonists & inhibitors*
Renin-Angiotensin System / drug effects*
Thiazoles / therapeutic use

Substances

Dipeptides
Peptides
Piperazines
Thiazoles
enalkiren
Renin
zankiren hydrochloride