Abstract
Background:
Human herpesvirus 6 (HHV-6), a widespread virus and causative agent of exanthema subitum in children, has been associated with a number of neurologic disorders including cranial nerve palsies, seizures, encephalitis, meningitis, and multiple sclerosis.
Patient:
A 31-year-old man presented with bilateral optic neuropathy, disc edema, and unilateral tonic pupil, which were found to be associated with acute HHV-6 infection. The patient had been suffering from juvenile diabetes for 5 years. One week after onset of intravenous antiviral therapy with foscarnet, disc edema subsided, and tonic pupil reaction was no longer detectable.
Conclusions:
HHV-6 infection may play a role as a causative agent in patients with optic neuropathy and tonic pupil.
MeSH terms
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Adult
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Antibodies, Viral / blood
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Antiviral Agents / therapeutic use
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Eye Infections, Viral / diagnosis
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Eye Infections, Viral / drug therapy
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Eye Infections, Viral / virology*
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Foscarnet / therapeutic use
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Herpesvirus 6, Human / immunology
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Herpesvirus 6, Human / isolation & purification*
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Humans
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Immunoglobulin G / analysis
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Immunoglobulin M / analysis
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Male
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Optic Nerve Diseases / diagnosis
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Optic Nerve Diseases / drug therapy
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Optic Nerve Diseases / virology*
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Papilledema / diagnosis
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Papilledema / drug therapy
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Papilledema / virology
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Roseolovirus Infections / diagnosis
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Roseolovirus Infections / drug therapy
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Roseolovirus Infections / virology*
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Tonic Pupil / diagnosis
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Tonic Pupil / drug therapy
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Tonic Pupil / virology*
Substances
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Antibodies, Viral
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Antiviral Agents
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Immunoglobulin G
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Immunoglobulin M
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Foscarnet